The 4th International Symposium by JSPS Core-to-Core Program"Cooperative International Framework in TGF-β Family Signaling

【Secretariat】
Department of
Molecular Pathology,
Graduate School of Medicine,
The University of Tokyo
Hongo 7-3-1, Bunkyo-ku,
Tokyo, Japan
Phone：+81-（0）3-5841-3356
Fax：+81-（0）3-5841-3354

Monday, January 12

08:15 –: Registration(International Congress Center EPOCHAL TSUKUBA)
Poster mounting

Opening Remarks

08:50 – 08:55: Mitsuyasu Kato (University of Tsukuba, Japan)

Session 1. Short talks (selected from poster abstracts)

Chair: Shinae Kondoh (Tokyo Institute of Technology, Japan)

09:00 – 09:20: Yutaro Tsubakihara(Ehime University, Japan)
(poster no.26)Arkadia induces ubiquitylation and degradation of Smad6
09:20 – 09:40: Kyung-Min Yang(CHA University, Korea)
(poster no.01)Cytoplasmic DRAK1 overexpressed in HNSCC cells inhibits TGF-β1 tumor suppressor activity
09:40 – 10:00: Takahiro Kuchimaru(Tokyo Institute of Technology, Japan)
(poster no.03)Non-invasive imaging of activation of HIF and TGF-β/Smad signaling in breast cancer progression
10:00 – 10:20: Ai Takemoto(Cancer Chemotherapy Center, JFCR, Japan)
(poster no.37)Aggrus-induced platelet aggregation promotes tumor metastasis by enhancing EMT
10:20 – 10:40: Masamitsu Konno(Osaka University, Japan)
(poster no.60)Embryonic MicroRNA-369 regulates Pyruvate kinase splicing form by stabilizing translation of splicing

10:40 – 11:40: Poster Viewing 1 (odd number) / Coffee Break

11:40 – 13:00: Lunch

Session 2. TGF–β signaling

Chair: Keiji Miyazawa (University of Yamanashi, Japan)

13:00 – 13:30: Carl–Henrik Heldin(Uppsala University, Sweden)
Mechanism of TGFβ-induced epithelial-mesenchymal transition
13:30 – 14:00: Aristidis Moustakas(Uppsala University, Sweden)
Regulation of BMP signaling during cell differentiation in human cancer
14:00 – 14:30: Mitsuyasu Kato(University of Tsukuba, Japan)
Roles of MafK and Gpnmb in malignant progression of breast cancer

Special Lecture 1

Chair: Carl–Henrik Heldin (Uppsala University, Sweden)

14:30 – 15:10: Seong–Jin Kim(CHA University of Medicine and Science, Korea)
Effects of Smad3 linker and C-tail phosphorylation on tumorigenesis and metastasis

15:10 – 16:10: Poster Viewing 2 (even number) / Coffee Break

Session 3. Cancer and metabolism-1

Chair: Takeshi Imamura (Ehime University, Japan)

16:10 – 16:40: Eiji Hara(Japanese Foundation for Cancer Research, Japan)
Cellular senescence and cancer: a gut microbial connection
16:40 – 17:10: Hiroyuki Suzuki(University of Tsukuba, Japan)
Roles of THG-1/Tsc22D4 in squamous cell carcinoma development

Special Lecture 2

Chair: Mitsuyasu Kato (University of Tsukuba, Japan)

17:10 – 17:50: Hiroaki Suga(The University of Tokyo, Japan)
Non-traditional drug discovery using artificial macrocycles for cancer therapeutics

Special Remarks

17:50 – 18:00: Kohei Miyazono (The University of Tokyo, Japan)

18:00 – 18:10: Group Photo

18:20 – 20:30: Banquet(International Congress Center EPOCHAL TSUKUBA)

: Poster Award

Tuesday, January 13

08:30 –: Registration(International Congress Center EPOCHAL TSUKUBA)

Session 3. Cancer and metabolism-2

Chair: Takeshi Imamura (Ehime University, Japan)

08:40 – 09:10: Hozumi Motohashi(Tohoku University, Japan)
Functional Nexus between Keap1-Nrf2 System and Cellular Metabolism

Session 4. Hematology and Immunology

Chair: Susumu Itoh (Showa Pharmaceutical University, Japan)

09:10 – 09:40: Shigeru Chiba(University of Tsukuba, Japan)
Clonal origin of microenvironmental cells in malignant lymphoma
09:40 – 10:10: Beate Heissig(The University of Tokyo, Japan)
The fibrinolytic system modulates the cytokine and cellular environment during cancer progression and chronic inflammation
10:10 – 10:40: Mizuko Mamura(Tokyo Medical University, Japan / Kyungpook National University, Korea)
Dynamic Smad signaling networks in immune cell regulation

10:40 – 11:00: Coffee Break

Session 5. Genome-wide approach

Chair: Hiroyuki Aburatani (The University of Tokyo, Japan)

11:00 – 11:30: Hiroyuki Aburatani(The University of Tokyo, Japan)
Coordinated chromatin regulation by developmental signals during cardiomyocyte differentiation
11:30 – 12:00: Daizo Koinuma(The University of Tokyo, Japan)
Identification of Smad regulatory factors through integrated analysis of ChIP-seq data
12:00 – 12:30: Masafumi Muratani(University of Tsukuba, Japan)
Ectopic induction of developmental gene regulatory network by cryptic promoters in gastric cancer

12:30 – 13:30: Lunch

Session 6. Angiogenesis

Chair: Yasufumi Sato (Tohoku University, Japan)

13:30 – 14:00: Marie–José Goumans(Leiden University, the Netherlands)
Impaired macrophage polarization in endoglin haplo-insufficiency leading to defective tissue repair
14:00 – 14:30: Tetsuro Watabe(Tokyo University of Pharmacy and Life Sciences, Japan)
Roles of signal networks during the formation and maintenance of tumor
vasculature
14:30 – 15:00: Nobuyuki Takakura(Osaka University, Japan)
Maintenance of the stemness in cancer stem cells requires CD44 expressed by tumor stromal cells via tissue hypoxia

Special Lecture

Chair: Kohei Miyazono (The University of Tokyo, Japan)

15:00 – 15:40: Gou–Young Koh(KAIST, Korea)
Targeting tumor vasculatures

15:40 – 16:00: Coffee Break
Poster unmounting

Session 7. Cancer therapy

Chair: Naoya Fujita (Japanese Foundation for Cancer Research, Japan)

16:00 – 16:30: Seiji Yano(Kanazawa University, Japan)
Bone microenvironment confers Hsp90 inhibitor resistance in the metastatic small cell lung cancer
16:30 – 17:00: Hiroyuki Mano(The University of Tokyo, Japan)
Targeting essential growth drivers in human cancer
17:00 – 17:30: Yoshihiro Kawasaki / Tetsu Akiyama(The University of Tokyo, Japan)
MYU, a novel target lncRNA for Wnt/c-Myc signaling, mediates CDK6 induction to promote cell cycle progression

Closing Remarks

17:30 – 17:40: Carl–Henrik Heldin(Uppsala University, Sweden)